8/6/2023 0 Comments Clindamycin headacheThe usual dose for adults is 150-300 mg (one or two capsules) four times daily, but the dose may be less than this if it is prescribed for a child. Take clindamycin exactly as your doctor tells you to.The manufacturer's leaflet will give you more information about the medicine and a full list of the side-effects which you may experience from taking it. Before you start taking clindamycin, read the manufacturer's printed information leaflet from inside the pack.Residerm 1% Gel (Crawford Healthcare Limited). Dalacin T Topical Lotion (Pfizer Limited). Clindamycin Phosphate Gel (Oceanside Pharmaceuticals). ![]() Clindamycin Phosphate Aerosol, Foam (Perrigo New York Inc). Clindamycin Palmitate Hydrochloride Solution (Greenstone LLC). Cleocin Suppository (Pharmacia and Upjohn Company LLC). Wolters Kluwer Clinical Drug Information, Inc. American Society of Health-System Pharmacists, Inc. Clindamycin ABM 150 mg Capsules data sheet 28 January 2018. Elimination half-life: Approx 3 hours 1.5-2.6 hours (vaginal cream) 11 hours (vaginal pessary).ĪBM Pharma Limited. 4%) and the remainder as inactive metabolites. Rapidly converted from biologically inactive clindamycin phosphate to active clindamycin (IV) or clindamycin hydrochloride (topical).Įxcretion: Via urine (Oral: Approx 10% Topical lotion, foam, solution: <0.2%) as active drug and metabolites, faeces (approx. Metabolism: Metabolised in the liver mainly via oxidation by CYP3A4 and to a lesser extent by CYP3A5 to form clindamycin sulfoxide (major metabolite) and N-desmethylclindamycin (minor metabolite). Time to peak plasma concentration: Within 1 hour (oral) 1-3 hours (IM) Approx 10-14 hours (vaginal cream) Approx 5 hours (vaginal pessary).ĭistribution: Widely distributed in body fluids (except CSF) and tissues, including bone. Oral: Reduced rate of absorption with food. As clindamycin phosphate: Minimally absorbed from the skin (approx 4-5%) and vagina (vaginal cream: approx 5% vaginal pessary: approx 30%). Potentially Fatal: Pseudomembranous colitis, Clostridium difficile-associated diarrhoea (CDAD), severe hypersensitivity reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS) gasping syndrome (in neonates).ĭescription: Clindamycin, a lincosamide antibiotic, inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit, thereby preventing the peptide bond formation, ribosome assembly and translation process.Ībsorption: As clindamycin hydrochloride: Rapidly absorbed from the gastrointestinal tract (approx 90%). Vascular disorders: Hypotension (IV), thrombophlebitis (IV). Skin and subcutaneous tissue disorders: Maculopapular rash, pruritus, erythema, seborrhoea, contact dermatitis. ![]() Reproductive system and breast disorders: Vulvovaginal irritation, vaginal moniliasis. Renal and urinary disorders: Azotaemia, oliguria, proteinuria. ![]() ![]() Nervous system disorders: Dysgeusia, headache, dizziness. Infections and infestations: Cervicitis, vaginal candidiasis, vaginitis. inflammation, irritation, burning sensation, pain, dryness, oiliness), inj site reactions (e.g. General disorders and admin site conditions: Application site reactions (e.g. Gastrointestinal disorders: Diarrhoea, abdominal pain, nausea, vomiting, oesophagitis, oesephageal ulcer. Blood and lymphatic system disorders: Leucopenia, agranulocytosis, eosinophilia, neutropenia, thrombocytopenia.
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